Research Program. Precision Nutrition and Cancer

Computational Biology

Group leader: Dr. Enrique Carrillo de Santa Pau

Objectives: Our group aims to apply integrative computational analyses and to develop bioinformatics resources to study the nutrition-disease interactions through molecular variability responses. Complex analytical strategies are key for understanding the relationships between food, genes, environment and diseases and to develop precision nutrition strategies based on individual molecular background. The group is currently focused on four topics:

1. Metabolic Variability to study the complex molecular relationships between food/diet bioactive compounds and drugs interactions from structured and unstructured resources.

2. Microbiome-Host interaction for characterizing the microbiome disruption in complex diseases like colorectal cancer or celiac disease and study the effects of food bioactive compounds in microbiome modulation for a healthy gut and precision nutrition strategies.

3. Bioinformatic tools development to integrate and facilitate the analysis, visualization and interpretation of complex, heterogeneous and disperse molecular food datasets.

4. Citizen Science bringing the science and knowledge generated in our group closer to the people.

Dr. Enrique Carrillo de Santa Pau

Group leader of the Computational Biology Group

Dr. Enrique Carrillo de Santa Pau, obtained his Bachelor’s degree (BSc) at the “Complutense” University (Madrid) in 2002. He completed a PhD training program (2002-2007) in Biochemistry and Molecular Biology at “Ramón y Cajal” Hospital. In 2007, he moved at Primary Health Care Service in Madrid to study Diabetes Mellitus as part of MADIABETES. He got an MsC in Bioinformatics and Computational Biology (UCM, 2009). In 2010 he joined Dr. Stunnenberg’s group at Nijmegen Centre for Molecular Life Sciences (The Netherlands) to study the role of 5hmC from a genome wide perspective. In 2011, he moved at Spanish National Cancer Research Centre (CNIO) where he was responsible for the bioinformatic analyses at the Carcinogenesis Epithelial Group lead by Dr. F.X. Real. In addition, he participated in the analysis of large-scale ‘omic’ datasets from the EU high impact initiative: “BLUEPRINT of Haematopoietic Epigenomes”, within Dr. A. Valencia’s group. From April 2018 he joined IMDEA Food Institute to lead the Computational Biology Group.

Phone: +34 91 727 81 00, ext. 304


Adrián Martín

Postdoctoral Researcher at Computational Biology Group

Adrian Martin obtained his Biochemistry Degree at Universidad Autonoma de Madrid (UAM) in 2011. The same year, he was awarded with La Caixa´s fellowship to pursue Master´s degree studies. He performed the Master in Biomedical Research at Universidad Pompeu Fabra in Barcelona between 2011 and 2012. He returned to Madrid in 2013, where he was awarded with a PhD fellowship FPU from the Education Ministry. He conducted his PhD studies between 2013 and 2017 in the Centro de Biologia Molecular (CBM) at UAM, under Dr. Carlos Dotti´s direction, working in insulin signaling in the hippocampus and its role in neuronal aging. In 2017 he obtained his PhD degree in Biochemistry at UAM and in 2018 he started a postdoctoral period at Dr. Ana Maria Cuervo´s laboratory in New York, working in the relationship between chaperone mediated autophagy (CMA) and the Parkinson´s neurodegenerative disease. In 2023 he was awarded with a Marie Curie Postdoctoral Fellowship from the European Commission to conduct studies related to aging and microbiome at IMDEA food institute.


Phone: +34 91 727 81 00


Jacobo Solórzano Gómez

Marco Garranzo Asensio

Illaria Pace

Juliana Estefanía Arcila Galvis


most relevant publications
  • Bergmann AK, Fataccioli V, Castellano G, Martin-Garcia N, Pelletier L, Ammerpohl O, Bergmann J, Bhat J, Carrillo de Santa Pau E, Martín-Subero JI, Moffitt AB, Valencia A, Oberg HH, Wesch D, Jayne S, Dyer MJS, Kabelitz D, Gaulard P, Siebert R. DNA methylation profiling of hepatosplenic T-cell lymphoma. Haematologica. 2019 Mar;104(3):e104-e107. doi: 10.3324/haematol.2018.196196. Epub 2018 Oct 18. PMID: 30337361; PMCID: PMC6395348.>
  • Isidoro Cobo; Paola Martinelli; Marta Flan-dez; Latifa Bakiri; Mingfeng Zhang; Enrique Carrillo-de-Santa-Pau; Jinping Jia; Liv Thom-mesen; Torunn Bruland; Natalia del Pozo; et al. Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas. Nature. 10.1038/nature25751, Nature Publishing Group, 2018. Available on-line at:
  • Enrique Carrillo-de-Santa-Pau*; David Juan*; Vera Pancaldi; Felipe Were; Ignacio Martin-Subero; Daniel Rico; Alfonso Valencia; BLUEPRINT Consortium. Automatic identification of informative regions with epigenomic changes associated to hematopoiesis. Nucleic acids research. 45 - 16, pp. 9244 - 9259. Oxford University Press, 2017. *Co-First authors.
  • Marcos-Zambrano LJ, Gómez A, Sánchez-Carrillo C, Bouza E, Muñoz P, Escribano P, Guinea J. Isavuconazole is highly active in vitro against Candida species isolates but shows trailing effect. Clin Microbiol Infect. 2020 Nov;26(11):1589-1592. doi: 10.1016/j.cmi.2020.07.023. Epub 2020 Jul 23. Erratum for: Clin Microbiol Infect. 2018 Dec;24(12):1343.e1-1343.e4. PMID: 32712246.
  • Bruch A, Laguna T, Butter F, Schaffrath R, Klassen R. Misactivation of multiple starvation responses in yeast by loss of tRNA modifications. Nucleic Acids Res. 2020 Jul 27;48(13):7307-7320. doi: 10.1093/nar/gkaa455. PMID: 32484543; PMCID: PMC7367188.
  • Marcos-Zambrano Laura Judith, Karaduzovic-Hadziabdic Kanita, Loncar Turukalo Tatjana, Przymus Piotr, Trajkovik Vladimir, Aasmets Oliver, Berland Magali, Gruca Aleksandra, Hasic Jasminka, Hron Karel, Klammsteiner Thomas, Kolev Mikhail, Lahti Leo, Lopes Marta B., Moreno Victor, Naskinova Irina, Org Elin, Paciência Inês, Papoutsoglou Georgios, Shigdel Rajesh, Stres Blaz, Vilne Baiba, Yousef Malik, Zdravevski Eftim, Tsamarindos Ioannis, Carrillo de Santa Pau Enrique, Claesson Marcus J., Moreno-Indias Isabel, Truu Jaak. Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment. Frontiers in Microbiology. 2021; 12:313. doi: 10.3389/fmicb.2021.634511
main research grants

Principal Investigator: Enrique Carrillo de Santa Pau
Participant Investigator: Teresa Laguna, Marco Garranzo & Carlos Madariaga
Project Title: Food Nutrition & Security Cloud (FNS-Cloud)
Date: 2019-2023
Funded by: H2020-EU., Grant agreement ID: 863059


Participant Investigator: Laura J. Marcos
Project Title: From Aging Biology to Sustainable Interventions: a microbiome-based anti-aging approach.
Date: 2020-2023
Funded by:Proyectos I+D+i 2019 - Retos Investigación. (PID2019-106893RA-100) . Ministerio de Ciencia, Innovación y Universidades


Participant Investigator: Enrique Carrillo de Santa Pau & Teresa Laguna
Project Title: Chronic DISease COntrol through VERY effective nutritional FORmulae (FORDISCOVERY)
Date: 2020-2022
Funded by: Proyectos I+D+i 2019 - Retos Investigación. (PID2019-107650RB-C22) . Ministerio de Ciencia, Innovación y Universidades


Participant Investigator: Enrique Carrillo de Santa Pau
Project Title: Fórmulas terapéuticas de nutrición de precisión para el cáncer - ALIBIRD2020-CM
Date: 2019-2022
Funded by: Comunidad de Madrid (P2018/BAA-4343)


Participant Investigator: Enrique Carrillo de Santa Pau & Laura J. Marcos
Project Title: COST Action CA18131 (“Statistical and machine learning techniques in human microbiome studies”)
Date: 2018-2022
Funded by: The European Cooperation in Science and Technology (COST)


Principal Investigator: Laura J. Marcos
Project Title: Profiling host-microbiome interactions in non-responding Celiac Disease symptoms persistence
Date: 2020-2021
Funded by: European Society of Clinical Microbiology and Infectious Diseases


Principal Investigator: Laura J. Marcos
Project Title: Picture your microbes: A co-creation participatory action to empower citizens on nutritional health decisions
Date: 2021
Funded by: European Institute of Innovation & Technology in Food


Participant Investigator: Enrique Carrillo de Santa Pau
Project Title:Nutritional strategies and bioactive compounds to target lipid metabolism alterations in cancer: Platform of Patient derived Paired Organoids for Precision Nutrition
Date: 2019-2021
Funded by: Fundación Ramón Areces


Participant Investigator: Enrique Carrillo de Santa Pau
Project Title:Development and validation of a predictive model of a fatal and non-fatal cardiovascular event after 10 years of follow-up of the Type 2 Diabetes Mellitus cohort from Madrid (MADIABETES)
Date: 2018-2021
Funded by: Fondo de Investigación Sanitaria. Instituto de Salud Carlos III (PI18/01025)