Precision Nutrition and Cardiometabolic Health

This Nutrition Precision Program has a mayor focus on the analysis of different features that allow of Personalised Nutrition interventions to be more efficient. These analyses have allowed to determine some specific clusters of population that predict higher benefits from the personalised dietary advice; to define the beneficial role of vegetable proteins in the weight management: the importance of a higher frequency nutritional feedback to achieve better results on body weight intervention and the identification of some specific methylation marks located at genes related with longevity-regulating pathways which were associated with obesity and metabolic syndrome traits.

miRNAs related to metabolic function are dysregulated in Huntington Disease patients microRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that govern complex biological processes with potential interest for therapeutic and diagnostics. miRNAs are found in all biological fluids. Compelling evidence suggest that miRNAs can be modulated by diet, but whether circulating miRNAs can be therapeutically targeted by the personalization of diet is unknown.

Some circulating miRNAs related to metabolic function are dysregulated in Huntington Disease (HD) patients. Unintentional weight loss (UWL) is a major clinical feature of symptomatic HD subjects. In a collaborative study with the Fundación Jiménez Díaz (Madrid) and ATG Medical (Madrid) we performed a pilot study to prevent UWL and to target metabolic circulating miRNAs through a dietary intervention. We found that a 12-month customized HD diet managed the UWL and modulated the dysregulated circulating miRNAs. Our results show that circulating miRNA can be therapeutically modulated through the personalization of diet and open up novel nutritional strategies to alleviate the devastating consequences of HD.

Neuroprotective activities of food products
The Bioactive Ingredients group discovered the potential neuroprotective activities of buttermilk and krill oil concentrates, in a model of aging. The two concentrates were tested in vivo. The molecular results indicate that these two preparations ameliorate several parameters associated with cognitive decline.