Research Program. Precision Nutrition and Aging
Nutritional Interventions Group
Group leader: Dr. Rafael de Cabo
Objectives: Our group is focused on understanding basic mechanisms underlying aging processes in order to develop and translate interventions aimed to preserve function late in life, to delay the onset of age-related diseases and to improve healthy life expectancy. The Nutritional Interventions Group focuses on energy restriction-based strategies applied to model organisms to decipher variations in energy demands and cellular energetic metabolism, a fundamental hallmark of the aging process
Dr. Rafael de Cabo
Senior investigator of the Experimental Gerontology Section at NIA (NIH-USA) and Program Director of the Precision Nutrition and Aging Program at IMDEA Food.
Rafael de Cabo, PhD is currently the chief of the Translational Gerontology Branch at the National Institute on Aging in Baltimore, Maryland. A native of Cordoba, Spain, he received his B.S. from the University of Cordoba, and his Ph.D. in 2000 from the Department of Foods and Nutrition at Purdue University. Upon completion of his graduate education, he trained as a postdoctoral fellow in the Laboratory of Neurosciences at the National Institute on Aging in Baltimore, Maryland. In 2004, he was appointed as a tenure track investigator in the Laboratory of Experimental Gerontology. His group applies both physiological and tissue-specific molecular approaches to investigate effects of nutritional interventions on basic mechanisms of aging and age-related diseases. Research within his unit strives to identify protective mechanisms invoked by caloric restriction and to evaluate the consequences of dietary interventions on lifespan, pathology, and behavioral function. Dr. de Cabo’s research balances the exploration of in vivo rodent, as well as in vitro, paradigms of caloric restriction.
Jose Luis López
Jose Luis Lopez is a highly skilled technician, with more than 7 years of experience in the management of mouse colonies and a wide range of experimental techniques in mouse models. He has worked in the Comparative Medicine Unit at the Spanish National Cardiovascular Research Center - CNIC, where he gained expertise in mouse colony databases. Currently, Jose Luis is the person in charge of mouse experiments of the Metabolic Syndrome Group at IMDEA Food, coordinating the mouse colonies housed in different animal facilities (CNB, CNIO, UAM), performing the most specific experiments and setting up different animal techniques. In addition, Jose Luis also supports different research lines using several molecular biology techniques, such as cell culture, confocal microscopy or q-PCR.
Phone: +34 91 727 81 00
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Principal Investigator: Alberto Díaz-Ruiz